post-training activation of LHb glutamatergic neurons disrupted object recognition and reward-based associative long-term memory
First-pass extracted concept
glutamatergic lateral habenula neurons
Candidate: concept label1 source documents5 linked claims
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Aliases
LHb glutamatergic neurons
Evidence Snippets
Supporting Sources
Linked Claims
Chemogenetic activation of glutamatergic lateral habenula neurons in mice impaired long-term associative memory.
Quoted textsource-backed
we used chemogenetic activation to temporarily excite glutamatergic neurons in the mouse LHb and assessed impacts on associative memory. Surprisingly, we found that transient activation of LHb impaired long-term memory
The findings indicate that glutamatergic lateral habenula neurons modulate consolidation of associative memories via an NMDA-mediated mechanism.
Quoted textsource-backed
indicating that LHb glutamatergic neurons modulate consolidation of associative memories via a NMDA-mediated mechanism
Systemic ketamine rescued the long-term memory deficits caused by LHb glutamatergic neuronal activation.
Quoted textsource-backed
pairing LHb glutamatergic neuronal activation with systemic ketamine administration rescued the long-term memory deficits
Post-training activation of LHb glutamatergic neurons disrupted object recognition and reward-based associative long-term memory while sparing fear-associated long-term memory.
Quoted textsource-backed
post-training activation of LHb glutamatergic neurons disrupted object recognition and reward-based associative long-term memory, while sparing fear associated long-term memory
The memory impairment caused by LHb glutamatergic neuron activation was restricted to a critical post-training or post-conditioning temporal window corresponding to long-term memory consolidation.
Quoted textsource-backed
The memory impairment was restricted to a critical temporal window post-training/conditioning that corresponded with the consolidation stage of long-term memory.