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glutamatergic LPBN neurons

Candidate: concept label1 source documents5 linked claims
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Evidence Snippets

CPN ligation increases nociceptive stimulation-induced responses in glutamatergic LPBN neurons; optogenetic activation or repetitive pharmacogenetic activation of glutamatergic LPBN neurons induces or mimics neuropathic pain-like behavior.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1activity change in disease modelsupports2020Source 1DOIPubMed

Common peroneal nerve ligation increases nociceptive stimulation-induced responses in glutamatergic LPBN neurons.

Claim 2causal perturbation effectsupports2020Source 1DOIPubMed

Inhibition of glutamatergic LPBN neurons alleviates basal nociception and neuropathic pain-like hypersensitivity.

Claim 3causal perturbation effectsupports2020Source 1DOIPubMed

Optogenetic activation of glutamatergic LPBN neurons or inhibition of GABAergic LPBN neurons induces neuropathic pain-like behavior in naive mice.

Claim 4causal perturbation effectsupports2020Source 1DOIPubMed

Repetitive pharmacogenetic activation of glutamatergic LPBN neurons mimics development of CPN ligation-induced neuropathic pain-like hypersensitivity, whereas repetitive pharmacogenetic activation of GABAergic LPBN neurons prevents it.

Claim 5mechanistic modelsupports2020Source 1DOIPubMed

A balance between excitatory and inhibitory LPBN neuronal activity governs the development and maintenance of neuropathic pain.