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glycolytic pathway enzymes

Candidate: concept label1 source documents3 linked claims
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Aliases

hexokinase, phosphofructokinase, pyruvate kinase M

Evidence Snippets

Key enzymes in the glycolytic pathway, such as hexokinase, phosphofructokinase, and pyruvate kinase M, play central roles in the metabolic reprogramming of HCC cells.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1functional effectsupports2026Source 1DOIPubMed

Aberrant activation of key glycolytic enzymes promotes rapid tumor cell proliferation and adaptability.

Quoted textsource-backed
Aberrant activation of these enzymes not only promotes swift proliferation of tumor cells but also boosts adaptability.
Claim 2mechanistic modelsupports2026Source 1DOIPubMed

Metabolic and signaling mechanisms interact synergistically to allow hepatocellular carcinoma cells to survive and proliferate despite targeted therapies, resulting in drug resistance.

Quoted textsource-backed
These mechanisms interact synergistically, allowing HCC cells to endure and proliferate despite targeted therapies, ultimately resulting in drug resistance.
Claim 3mechanistic rolesupports2026Source 1DOIPubMed

Hexokinase, phosphofructokinase, and pyruvate kinase M play central roles in metabolic reprogramming of hepatocellular carcinoma cells.

Quoted textsource-backed
Key enzymes in the glycolytic pathway, such as hexokinase, phosphofructokinase, and pyruvate kinase M, play central roles in the metabolic reprogramming of HCC cells.