The glymphatic system is a glial-dependent waste clearance pathway in the central nervous system, devoted to drain away waste metabolic products and soluble proteins such as amyloid-beta.
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glymphatic system
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Evidence Snippets
SD is also shown to affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline.
Smaller blood clots may obstruct the perivascular (Virchow-Robin) space and thereby the glymphatic system with detrimental consequences for cerebrospinal fluid (CSF)/interstitial fluid (ISF) flow.
Supporting Sources
Linked Claims
Sleep deprivation affects the glymphatic system, a glial-dependent metabolic waste clearance pathway, and is associated with accumulation of misfolded proteins in synaptic compartments and cognitive decline.
The review proposes that after intraventricular rt-PA therapy, smaller clots and blood derivatives can enter perivascular spaces, obstruct glymphatic clearance, and impair CSF/ISF flow.
Obstruction and insufficient function of arterial granulations by ISF containing blood cells and proteins is proposed to contribute to malresorptive hydrocephalus after IVH.