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GPR183

Candidate: concept label1 source documents5 linked claims
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Aliases

oxysterol receptor GPR183

Evidence Snippets

Here, we discovered that the oxysterol receptor GPR183 positions monocytes to sense niche signals that induce lung macrophage differentiation.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1differentiation trajectory expressionsupports2026Source 1DOIPubMed

Newcomer monocyte-derived macrophages express GPR183 along their differentiation trajectory after conditional tissue-resident macrophage depletion.

Claim 2expression patternsupports2026Source 1DOIPubMed

Interstitial macrophages express GPR183 whereas alveolar macrophages do not.

Claim 3instructive signalsupports2026Source 1DOIPubMed

Oxysterols act as instructive signals for tissue-resident macrophage development from monocytes.

Claim 4loss of function phenotypesupports2026Source 1DOIPubMed

Lack of GPR183 causes defective lung macrophage differentiation.

Claim 5mechanistic rolesupports2026Source 1DOIPubMed

GPR183 positions monocytes to sense niche signals that induce lung macrophage differentiation.