First-pass extracted concept

Gpr45

Candidate: concept label1 source documents4 linked claims

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Supporting Sources

Source 1primary paper2025MEDDOI PubMed

0 evidence snippets 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1anatomical site of actionsupports2025Source 1DOI PubMed

Targeted deletion of Gpr45 from the PVH phenocopies obesity and hyperphagia, supporting the PVH glutamatergic population as a major site of Gpr45 action.

Claim 2cell type specificitysupports2025Source 1DOI PubMed

Selective deletion of Gpr45 in Sim1-positive or Vglut2-positive neurons, but not Vgat-positive neurons, produces obesity and hyperphagia.

Claim 3functional rolesupports2025Source 1DOI PubMed

Global disruption of Gpr45 causes weight gain, increased food intake, and increased fat mass without detectable changes in core temperature or energy output.

Claim 4therapeutic relevancesupports2025Source 1DOI PubMed

Gpr45 is presented as a putative therapeutic candidate for combating obesity and overeating.