The abstract describes GBP2 as an interferon-inducible GTPase involved in innate immunity, cancer-related signaling, and broader disease contexts.
First-pass extracted concept
Guanylate-binding protein 2
Candidate: concept label1 source documents4 linked claims
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Aliases
GBP2
Extracted Explainers
Evidence Snippets
Supporting Sources
Linked Claims
GBP2 has a context-dependent dual role in cancer, acting either as a tumor suppressor or as an oncogene.
Quoted textsource-backed
Beyond infectious disease, GBP2 demonstrates a context-dependent dual role in cancer-acting as either a tumor suppressor or an oncogene...
GBP2 plays a critical role in innate immunity by defending against viral, bacterial, and parasitic infections through mechanisms including furin inhibition and inflammasome activation.
Quoted textsource-backed
Guanylate-binding protein 2 (GBP2) is an interferon-inducible GTPase that plays a critical role in innate immunity by defending against viral, bacterial, and parasitic infections through mechanisms such as furin inhibition and inflammasome activation.
GBP2 modulates cancer-relevant signaling pathways including JAK-STAT, Wnt/β-catenin, and PI3K/AKT/mTOR.
Quoted textsource-backed
...by modulating key signaling pathways including JAK-STAT, Wnt/β-catenin, and PI3K/AKT/mTOR.
GBP2 dysregulation is implicated in autoimmune, neurological, and metabolic disorders and supports its potential use as a diagnostic biomarker and therapeutic target.
Quoted textsource-backed
Its dysregulation is also increasingly implicated in autoimmune, neurological, and metabolic disorders, underscoring its promising utility as a diagnostic biomarker and therapeutic target.