First-pass extracted concept

heat shock proteins

Candidate: concept label2 source documents6 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

HSPs

Evidence Snippets

Several mechanisms are involved in the protective responses to PDT including the expression of chaperone/heat shock proteins (HSPs).

Evidence 1Source 1DOI PubMedprovenance

The necessity to focus on the role of anti-inflammatory mediators, as well as the pathogenetic significance of important molecular groups, such as the heat shock proteins, which until now have been given scant attention, will be stressed.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2016Photochemical & Photobiological SciencesDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Source 2review2000The Journal of PathologyDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1functional summarysupports2016Source 1DOI PubMed

Heat shock proteins can promote cell survival through cytoprotective mechanisms.

Quoted textsource-backed

it has been discovered that HSPs can play an important role in cell survival, due to the fact that they are responsible for many cytoprotective mechanisms

Claim 2mechanistic summarysupports2016Source 1DOI PubMed

Extracellular or membrane-bound heat shock proteins mediate immunological functions.

Quoted textsource-backed

In contrast, extracellular HSPs or membrane-bound HSPs mediate immunological functions.

Claim 3mechanistic summarysupports2016Source 1DOI PubMed

Heat shock protein expression is part of the protective cellular response to photodynamic therapy.

Quoted textsource-backed

Several mechanisms are involved in the protective responses to PDT including the expression of chaperone/heat shock proteins (HSPs).

Claim 4mechanistic summarysupports2016Source 1DOI PubMed

Intracellular heat shock proteins are associated with anti-apoptotic function, and HSP-induced autophagy is described as protective.

Quoted textsource-backed

In general, intracellular HSPs have been related to an anti-apoptotic function and recently, HSP-induced autophagy has shown to have a protective role in these chaperones.

Claim 5review scope summarysupports2016Source 1DOI PubMed

The review discusses how certain photodynamic therapy protocols may optimally stimulate the immune system through heat shock proteins.

Quoted textsource-backed

We will also discuss how certain PDT protocols optimally stimulate the immune system through HSPs.

Claim 6research prioritysupports2000Source 2DOI PubMed

The review argues that anti-inflammatory mediators and heat shock proteins deserve greater attention in sepsis microcirculatory pathogenesis and therapy discussions.