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First-pass extracted concept

Hedgehog signaling

Candidate: concept label1 source documents4 linked claims
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Aliases

Hedgehog family, Hedgehog signaling pathway

Extracted Explainers

What the tool is doing

Hedgehog signaling is presented as an intercellular signaling system that regulates embryonic growth, patterning, and morphogenesis. The review treats it as a conserved developmental signaling paradigm in Drosophila and vertebrates.

Source 1DOIPubMed

What problem it solves

It explains how a small family of secreted signals can control distinct cell fates, proliferation, and organ form during development.

Source 1DOIPubMed

What it does not solve

The abstract explicitly notes unresolved questions about how Hedgehog proteins move across cell fields, how their activities are modulated and transduced, and what their intracellular targets are.

Source 1DOIPubMed

Alternatives

The abstract contrasts Hedgehog with other major secreted signaling families including Wnt, fibroblast growth factor, TGF superfamily, platelet-derived growth factor, and ephrin.

Source 1DOIPubMed

Evidence Snippets

Members of the Hedgehog family of intercellular signaling proteins are described as key mediators of embryonic development, with the review surveying Hedgehog function, synthesis, modification, and transduction.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1conservation summarysupports2001Source 1DOIPubMed

Deployment of Hedgehog family signaling is strikingly conserved between invertebrate and vertebrate developmental systems.

Quoted textsource-backed
parallel studies in invertebrate and vertebrate systems have shown that although the final outcome might look quite different (e.g., a fly vs. a mouse), there is a striking conservation in the deployment of members of the same signaling families to regulate development
Claim 2developmental function summarysupports2001Source 1DOIPubMed

Hedgehog activities are central to growth, patterning, and morphogenesis in many regions of vertebrate and insect body plans.

Quoted textsource-backed
Their activities are central to the growth, patterning, and morphogenesis of many different regions within the body plans of vertebrates and insects
Claim 3functional role summarysupports2001Source 1DOIPubMed

Hedgehog family proteins are key mediators of many fundamental processes in embryonic development.

Quoted textsource-backed
members of the Hedgehog family of intercellular signaling proteins have come to be recognized as key mediators of many fundamental processes in embryonic development
Claim 4mechanistic mode summarysupports2001Source 1DOIPubMed

Depending on context, Hedgehog signals can act as morphogens, mitogens, or inducing factors during development.

Quoted textsource-backed
In some contexts, Hedgehog signals act as morphogens in the dose-dependent induction of distinct cell fates within a target field, in others as mitogens regulating cell proliferation or as inducing factors controlling the form of a developing organ.