The abstract describes the heme oxygenase pathway as part of an anti-degenerative stress-response system in Alzheimer's disease. HO induction is said to generate carbon monoxide and bilirubin, which are linked to protection against brain oxidative injury.
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heme oxygenase pathway
Candidate: concept label2 source documents8 linked claims
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HO pathway
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The abstract also discusses exogenous antioxidant supplementation, including vitamin E and polyphenolic agents such as curcumin and its derivatives.
The heat shock response more broadly is discussed as a parallel endogenous defense mechanism, and nutritional antioxidants or pharmacological compounds are presented as ways to engage such pathways.
Evidence Snippets
the heme oxygenase (HO) pathway in anti-degenerative mechanisms operating in AD
Here we review the importance of the heme oxygenase pathway in brain stress tolerance and its significance as an antidegenerative mechanism potentially important in AD pathogenesis.
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Linked Claims
The review states that maintenance or recovery of vitagene activity such as the heme oxygenase gene may delay aging and decrease age-related neurodegenerative diseases.
Quoted textsource-backed
maintenance or recovery of the activity of vitagenes, such as the HO gene, conceivably may delay the aging process and decrease the occurrence of age-related neurodegenerative diseases
Expression of heme oxygenase is closely related to expression of amyloid precursor protein.
The review states that carbon monoxide and bilirubin, products of the heme oxygenase reaction, represent a protective system potentially active against brain oxidative injury.
Quoted textsource-backed
The vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, products of HO-catalyzed reaction, represent a protective system potentially active against brain oxidative injury.
The review states that heme oxygenase induction occurs together with induction of other heat shock proteins during various physiopathological conditions.
Quoted textsource-backed
HO induction occurs together with the induction of other HSPs during various physiopathological conditions.
The review states that the heme oxygenase pathway is important in brain stress tolerance and is a potentially antidegenerative mechanism in Alzheimer's disease pathogenesis.
Quoted textsource-backed
Here we review the importance of the heme oxygenase pathway in brain stress tolerance and its significance as an antidegenerative mechanism potentially important in AD pathogenesis.
Heme oxygenase induction generates carbon monoxide and bilirubin and represents a protective system potentially active against brain oxidative injury.
The review states that oxidative stress and disturbed protein metabolism, and their interaction, are central to Alzheimer's disease pathogenesis.
Quoted textsource-backed
increasing evidence indicates that factors such as oxidative stress and disturbed protein metabolism and their interaction in a vicious cycle are central to AD pathogenesis
The heme oxygenase pathway is presented as an anti-degenerative stress-tolerance mechanism relevant to Alzheimer's disease pathogenesis.