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First-pass extracted concept

Hepatitis B surface antigen

Candidate: concept label1 source documents5 linked claims
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Aliases

HBsAg

Evidence Snippets

Here, we reported that HBsAg suppressed type I interferon production and induced the accumulation of autophagosomes.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1mechanismsupports2025Source 1DOIPubMed

HBsAg blocks autophagosome-lysosome fusion by inhibiting the SNAP29 promoter.

Claim 2mechanismsupports2025Source 1DOIPubMed

HBsAg-enhanced TBK1 dimerization promotes p62 phosphorylation and is necessary for HBV-induced autophagy and HBV replication.

Claim 3mechanismsupports2025Source 1DOIPubMed

HBsAg increases TBK1 phosphorylation and decreases IRF3 phosphorylation ex vivo and in vivo.

Claim 4mechanismsupports2025Source 1DOIPubMed

HBsAg interacts with the kinase domain of TBK1, augments TBK1 dimerization, and disrupts TBK1-IRF3 complexes.

Claim 5mechanismsupports2025Source 1DOIPubMed

HBsAg suppresses type I interferon production and induces accumulation of autophagosomes.