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hepatitis C virus p7 hexamer

Candidate: concept label1 source documents4 linked claims
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Aliases

p7 hexamer

Evidence Snippets

Using the hepatitis C virus p7 hexamer as a representative of proteins with complex transmembrane topology, this work characterizes early lipid-driven dimerization using molecular dynamics simulations.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1general conclusionsupports2025Source 1DOIPubMed

Membrane lipids are essential, dynamic contributors to protein binding and aggregation in cellular membranes.

Quoted textsource-backed
This study demonstrates that membrane lipids are essential, dynamic contributors to protein binding and aggregation in cellular membranes.
Claim 2mechanistic insightsupports2025Source 1DOIPubMed

Compared with aqueous solution, a lipid membrane model reveals that protein-lipid interactions critically guide inter-protein residue alignment and binding during p7 dimer interactions.

Quoted textsource-backed
Comparing dimer interactions in aqueous solution versus on a lipid membrane model reveal that protein-lipid interactions critically guide inter-protein residue alignment and binding.
Claim 3mechanistic insightsupports2025Source 1DOIPubMed

Hydrophobic contacts and hydrogen bonding between key residues and phosphatidylcholine/phosphatidylinositol lipids drive helix interactions that promote p7 oligomerization, particularly involving the first helix.

Quoted textsource-backed
Hydrophobic contacts and hydrogen bonding between key residues and phosphatidylcholine/phosphatidylinositol lipids drive essential helix interactions that promote p7 oligomerization, particularly involving the first helix.
Claim 4mechanistic insightsupports2025Source 1DOIPubMed

Molecular dynamics simulations characterize early lipid-driven dimerization of hepatitis C virus p7.

Quoted textsource-backed
Using the hepatitis C virus p7 hexamer as a representative of proteins with complex transmembrane topology, this work characterizes early lipid-driven dimerization using molecular dynamics simulations.