Collectively, we show here, for the first time, that HIF-1α is a novel molecular target for the 2-aminopyrrole derivative (2-ANPC).
First-pass extracted concept
HIF-1α as a molecular target of 2-ANPC
Candidate: concept label1 source documents5 linked claims
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Aliases
Hypoxia-inducible factor-1α target relationship
Evidence Snippets
Supporting Sources
Linked Claims
Computational analysis identified four potential binding sites for 2-ANPC to interact with HIF-1α, HIF-1β, and the p300 complex.
Quoted textsource-backed
using various computational tools, we identified four potential binding sites for 2-ANPC to interact with HIF-1α, HIF-1β, and the p300 complex.
2-ANPC downregulates HIF-1α in vivo in the 4T1 breast cancer syngeneic model.
Quoted textsource-backed
2-ANPC's potency in downregulating HIF-1α was also shown in vivo by using the 4T1 breast cancer syngraft model.
2-ANPC-mediated HIF-1α downregulation is due to enhanced proteasome-mediated degradation and is reversed by MG-132.
Quoted textsource-backed
The downregulation of HIF-1α expression in 2-ANPC-treated cancer cells was due to enhanced proteasome-mediated degradation, whereas the proteasome inhibitor MG-132 effectively reversed this downregulation.
HIF-1α is presented as a novel molecular target for 2-ANPC.
Quoted textsource-backed
we show here, for the first time, that HIF-1α is a novel molecular target for the 2-aminopyrrole derivative (2-ANPC)
2-ANPC downregulates HIF-1α expression in breast, lung, and prostate cancer cell lines.
Quoted textsource-backed
2-ANPC ... effectively downregulates HIF-1α expression in a broad spectrum of cancer cell lines, including breast, lung, and prostate cancer.