First-pass extracted concept

HIF-1 signaling pathway

Candidate: concept label2 source documents1 linked claims

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This article summarizes available information on the effects of pentacyclic triterpenoids on the ... HIF-1α ... signaling pathways in ovarian cancer cells.

Evidence 1Source 1DOI PubMedprovenance

The present review elucidates the capacity of andrographolide to inhibit signaling pathways, namely... hypoxia-inducible factor 1 (HIF-1)...

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

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Source 2review2024MEDDOI PubMed

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Linked Claims

Claim 1review scopesupports2025Source 1DOI PubMed

The article summarizes available information on the effects of pentacyclic triterpenoids on PI3K/AKT/mTOR, MAPK/ERK, NF-κB, JAK/STAT, Notch, HIF-1α, TGF-β, Wnt/β-catenin, Hippo, and Hedgehog signaling pathways in ovarian cancer cells.

Quoted textsource-backed

This article summarizes available information on the effects of pentacyclic triterpenoids on the PI3K/AKT/mTOR, MAPK/ERK, NF-κB, JAK/STAT, Notch, HIF-1α, TGF-β, Wnt/β-catenin, Hippo, and Hedgehog signaling pathways in ovarian cancer cells.