First-pass extracted concept

HIF-1a-regulated hypoxia-induced glycolysis

Candidate: concept label1 source documents3 linked claims

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Aliases

HIF-1a regulated glycolysis, hypoxia-induced glycolysis

Evidence Snippets

tumor hypoxia, which drives metabolic reprogramming (especially reconfiguration towards glycolysis), mediated to a great extent by hypoxia-inducible factor-"HIF-1 alpha" (HIF-1a)

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease associationsupports2026Source 1DOI PubMed

HIF-1a-driven hypoxia is a common phenotypic feature in prostate cancer that underlies increased glycolysis and an aggressive tumor phenotype.

Claim 2mechanistic rolesupports2026Source 1DOI PubMed

In prostate cancer, tumor hypoxia drives metabolic reprogramming toward glycolysis and this is mediated to a great extent by HIF-1a.

Claim 3platform summarysupports2026Source 1DOI PubMed

Theranostic nanoparticles are a promising platform for integrating diagnosis and treatment of prostate cancer through targeted delivery, on-line monitoring, and interference with HIF-1a-regulated glycolysis.