Back to first-pass browser

First-pass extracted concept

high-affinity glutamate transporters

Candidate: concept label1 source documents5 linked claims
Jump to explainersJump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Aliases

GluTs, SLC1A family of high-affinity glutamate transporters

Extracted Explainers

What the tool is doing

High-affinity glutamate transporters are described as plasma membrane systems that regulate extracellular glutamate and thereby modulate excitatory signaling in spinal pain circuits.

Source 1DOIPubMed

What problem it solves

They address excessive or dysregulated glutamatergic signaling linked to chronic pain and analgesia-related mechanisms.

Source 1DOIPubMed

What it does not solve

The abstract does not support a single precise therapeutic implementation because subtype-specific regulation and splice-variant biology remain unresolved.

Source 1DOIPubMed

Alternatives

The review contrasts transporter upregulation strategies with transporter inhibition or antisense down-regulation, which are associated with worsened pain behaviors.

Source 1DOIPubMed

Evidence Snippets

Members of the SLC1A family of high-affinity glutamate transporters (GluTs) are differentially expressed in sensory neurons and surrounding glial cells.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1disease relevancesupports2014Source 1DOIPubMed

Emerging data implicate glutamate transporters in molecular mechanisms of chronic pain, analgesia, and opioid tolerance.

Claim 2intervention effectsupports2014Source 1DOIPubMed

Increasing glutamate transporter expression by viral gene transfer or positive pharmacological modulators can mitigate chronic pain.

Claim 3intervention effectsupports2014Source 1DOIPubMed

Pharmacological inhibition or antisense down-regulation of spinal glutamate transporters can induce or aggravate pain behaviors.

Claim 4mechanistic rolesupports2014Source 1DOIPubMed

High-affinity glutamate transporters regulate extracellular glutamate concentrations and modulate excitatory signaling in spinal pain circuits.

Claim 5translation limitationsupports2014Source 1DOIPubMed

Precise pharmacological targeting of glutamate transporters for pain therapy requires deeper understanding of molecular factors and signaling pathways controlling individual transporter subtypes and splice variants.