This paper studies repeated inhalational exposure to high-THC cannabis smoke during rat gestation as the experimental perturbation. It is used to test effects on maternal physiology and offspring neurobehavioral and amygdala gene-expression outcomes.
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high-THC cannabis smoke gestational exposure
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Cannabis smoke exposure, repeated exposure to high-THC Cannabis smoke during gestation
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Adult male and female offspring exposed to gestational cannabis smoke explored the inner zone of an open field less than controls.
Cannabis-exposed offspring performed better on visual pairwise discrimination and reversal learning tasks in touchscreen-equipped operant conditioning chambers.
Female Sprague Dawley rats were exposed daily to cannabis smoke from gestational day 6 to 20, with room air as control.
RNA sequencing of adult amygdala revealed subtle gene-expression changes related to development, cellular function, and nervous system disease in a subset of male offspring after gestational cannabis smoke exposure.
Cannabis smoke exposure did not alter maternal weight gain, food intake, gestational length, litter number, or litter weight.
Gestational cannabis smoke exposure did not affect offspring behavior on the elevated plus maze or social interaction test.
Cannabis-exposed litters had a significantly increased male-to-female sex ratio.
Cannabis smoke-exposed dams showed more fecal boli in the chambers before and after smoke exposure.
Cannabis smoke exposure decreased body temperature in pregnant dams.