First-pass extracted concept

hippocampal-prefrontal interactions

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

The goal of this review is to summarize what is known about the role of hippocampal-prefrontal interactions in normal brain function and compare how these interactions are disrupted in schizophrenia patients and animal models of the disease.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2016Frontiers in Systems NeuroscienceDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1animal model summarysupports2016Source 1DOI PubMed

Animal model studies have begun to relate disruptions in hippocampal-prefrontal interactions to schizophrenia risk factors and pathophysiological mechanisms.

Claim 2disease associationsupports2016Source 1DOI PubMed

Hippocampal-prefrontal interactions are disrupted in psychiatric disease and may contribute to pathophysiology.

Claim 3disease associationsupports2016Source 1DOI PubMed

Impairments in hippocampal-prefrontal interactions have most frequently been observed in schizophrenia.

Claim 4review scope summarysupports2016Source 1DOI PubMed

Electrophysiological and functional imaging studies have begun to examine how hippocampal-prefrontal interactions contribute to behavior during tasks.