First-pass extracted concept

histone lactylation

Candidate: concept label2 source documents4 linked claims

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Aliases

lactylation modification

Extracted Explainers

What the tool is doing

The abstract presents histone lactylation as a lactate-linked post-translational modification involved in epigenetic regulation.

Source 2DOI PubMed

What problem it solves

It is framed as a mechanism that may help explain macrophage polarization in sepsis.

Source 2DOI PubMed

Evidence Snippets

long-term epigenetic programming via histone lactylation establishes a stable immunosuppressive transcriptome

Evidence 1Source 1DOI PubMedprovenance

Lactate generated by aerobic glycolysis is an essential substrate for the tricarboxylic acid cycle and for post-translational modifications via histone lactylation and epigenetic regulation.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 2primary paper2025MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic modelsupports2026Source 1DOI PubMed

The proposed metabolic-epigenetic axis links lactylation to immunosuppression through two synergistic mechanisms: histone lactylation for stable epigenetic programming and non-histone lactylation for rapid modulation of protein activity and stability.

Claim 2knowledge gapsupports2025Source 2DOI PubMed

The roles of lactate and lactylation modification in sepsis remain unclear.

Claim 3mechanistic rolesupports2025Source 2DOI PubMed

Lactate generated by aerobic glycolysis serves as a substrate for the tricarboxylic acid cycle and for histone lactylation-associated epigenetic regulation.

Claim 4therapeutic potentialsupports2025Source 2DOI PubMed

Regulation by lactate and lactylation during macrophage polarization in sepsis may represent a potential therapeutic target for sepsis.