First-pass extracted concept

homology-directed repair

Candidate: concept label2 source documents3 linked claims

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Aliases

HDR, homologous recombination

Evidence Snippets

This one-plasmid system induces Cas9-mediated double-strand breaks and exploits native DNA repair: homologous recombination for scarless deletions and gene replacements... Using homology-directed repair, we deleted the katA and ald genes...

Evidence 1Source 1DOI PubMedprovenance

These techniques depend on two main DNA repair mechanisms: homology-directed repair (HDR), which facilitates precise changes to the genome

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 2primary paper2025MEDDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Linked Claims

Claim 1mechanismsupports2025Source 1DOI PubMed

The one-plasmid CRISPR-Cas9 system uses homologous recombination for scarless deletions and gene replacements and error-prone end-joining repair for mutagenesis without a repair template.

Claim 2mechanism rolesupports2025Source 2DOI PubMed

Gene editing techniques depend on HDR and NHEJ as two main DNA repair mechanisms.

Quoted textsource-backed

These techniques depend on two main DNA repair mechanisms: homology-directed repair (HDR) ... and non-homologous end joining (NHEJ)

Claim 3mechanistic propertysupports2025Source 2DOI PubMed

HDR facilitates precise changes to the genome.

Quoted textsource-backed

homology-directed repair (HDR), which facilitates precise changes to the genome