Hormone-sensitive lipase (HSL) is one of the three lipases in adipose tissue present during periods of energy demand.
First-pass extracted concept
Hormone-sensitive lipase
Candidate: concept label1 source documents6 linked claims
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Aliases
HSL
Evidence Snippets
Supporting Sources
Linked Claims
Insulin's inhibitory effect on HSL can be overridden in the context of insulin-induced hypoglycemia.
Quoted textsource-backed
a rapid elevation of HSL levels was detected after insulin injection in patients, which suggests that the inhibitory effects of insulin on HSL can be overridden by insulin-induced hypoglycemia
Hereditary HSL deficiency and experimental HSL deletion are associated with disrupted insulin signaling and metabolic disease phenotypes including insulin resistance, diabetes, and fatty liver.
Quoted textsource-backed
individuals with hereditary HSL deficiency, and animals with experimental HSL deletion, showed major disruptions in mRNA/protein expression in insulin signaling pathways, ultimately leading to insulin resistance, diabetes, and fatty liver
HSL inactivation can cause insulin-independent fatty liver, and HSL-deficiency-associated insulin resistance may further worsen disease progression.
Quoted textsource-backed
HSL inactivation could cause insulin-independent fatty liver, while insulin resistance induced by HSL deficiency may further aggravate disease progression.
Recent discoveries challenge the assumptions that HSL is the overall rate-limiting enzyme in lipolysis and that insulin is simply an inhibitor of HSL.
Quoted textsource-backed
The common beliefs that HSL is the overall rate-limiting enzyme in lipolysis and that insulin is an inhibitor of HSL have been challenged by recent discoveries
Insulin regulates HSL at multiple levels including isoform transcription, post-transcriptional phosphorylation effects involving PKA and endothelin, and indirect control through growth hormone activity.
Quoted textsource-backed
Insulin not only differentially regulates HSL isoform transcription but also post-transcriptionally affects HSL phosphorylation by stimulating PKA and endothelin (ET-1), and controls its expression indirectly via regulating the activity of growth hormone (GH).
Insulin tightly regulates hormone-sensitive lipase through central and peripheral mechanisms.
Quoted textsource-backed
HSL is tightly controlled by insulin regulation via the central and peripheral systems.