First-pass extracted concept

HsAtg4

Candidate: concept label1 source documents3 linked claims

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Aliases

Atg4

Evidence Snippets

Furthermore, we identify the cysteine protease HsAtg4 as a direct target for oxidation by H(2)O(2), and specify a cysteine residue located near the HsAtg4 catalytic site as a critical for this regulation.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2007The EMBO JournalDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1direct target regulationsupports2007Source 1DOI PubMed

HsAtg4 is a direct target for oxidation by H2O2.

Claim 2functional perturbationsupports2007Source 1DOI PubMed

Expression of a regulatory HsAtg4 mutant prevented autophagosome formation in cells.

Claim 3residue level regulationsupports2007Source 1DOI PubMed

A cysteine residue near the HsAtg4 catalytic site is critical for redox regulation of HsAtg4.