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First-pass extracted concept

HSL-insulin regulatory axis

Candidate: concept label1 source documents6 linked claims
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Extracted Explainers

What the tool is doing

This concept captures the mutual regulation between HSL and insulin described throughout the review. It is useful as a curation label for literature on lipolysis-insulin crosstalk in metabolic disease.

Source 1DOIPubMed

What problem it solves

It provides a compact way to group studies on how insulin regulates HSL and how HSL deficiency feeds back onto insulin signaling.

Source 1DOIPubMed

Evidence Snippets

Elucidation of the intricate relationships between HSL and insulin may provide an in-depth understanding of these pandemic diseases and potentially identify strategies to inhibit disease development.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1context dependent regulationsupports2019Source 1DOIPubMed

Insulin's inhibitory effect on HSL can be overridden in the context of insulin-induced hypoglycemia.

Quoted textsource-backed
a rapid elevation of HSL levels was detected after insulin injection in patients, which suggests that the inhibitory effects of insulin on HSL can be overridden by insulin-induced hypoglycemia
Claim 2disease associationsupports2019Source 1DOIPubMed

Hereditary HSL deficiency and experimental HSL deletion are associated with disrupted insulin signaling and metabolic disease phenotypes including insulin resistance, diabetes, and fatty liver.

Quoted textsource-backed
individuals with hereditary HSL deficiency, and animals with experimental HSL deletion, showed major disruptions in mRNA/protein expression in insulin signaling pathways, ultimately leading to insulin resistance, diabetes, and fatty liver
Claim 3disease mechanismsupports2019Source 1DOIPubMed

HSL inactivation can cause insulin-independent fatty liver, and HSL-deficiency-associated insulin resistance may further worsen disease progression.

Quoted textsource-backed
HSL inactivation could cause insulin-independent fatty liver, while insulin resistance induced by HSL deficiency may further aggravate disease progression.
Claim 4field reassessmentsupports2019Source 1DOIPubMed

Recent discoveries challenge the assumptions that HSL is the overall rate-limiting enzyme in lipolysis and that insulin is simply an inhibitor of HSL.

Quoted textsource-backed
The common beliefs that HSL is the overall rate-limiting enzyme in lipolysis and that insulin is an inhibitor of HSL have been challenged by recent discoveries
Claim 5mechanistic summarysupports2019Source 1DOIPubMed

Insulin regulates HSL at multiple levels including isoform transcription, post-transcriptional phosphorylation effects involving PKA and endothelin, and indirect control through growth hormone activity.

Quoted textsource-backed
Insulin not only differentially regulates HSL isoform transcription but also post-transcriptionally affects HSL phosphorylation by stimulating PKA and endothelin (ET-1), and controls its expression indirectly via regulating the activity of growth hormone (GH).
Claim 6regulatory relationshipsupports2019Source 1DOIPubMed

Insulin tightly regulates hormone-sensitive lipase through central and peripheral mechanisms.

Quoted textsource-backed
HSL is tightly controlled by insulin regulation via the central and peripheral systems.