First-pass extracted concept

HTLV-1 immature capsid lattice

Candidate: concept label1 source documents4 linked claims

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Aliases

HTLV-1 capsid (CA) lattice, immature CA lattice

Evidence Snippets

Here, we characterize the immature CA lattice from immature virus particles by using cryo-electron microscopy and tomography (cryo-EM/ET).

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1cofactor requirementsupports2025Source 1DOI PubMed

IP6 is dispensable for HTLV-1 immature particle assembly and proper immature lattice formation.

Quoted textsource-backed

Intriguingly, inositol hexakisphosphate (IP6) is dispensable for HTLV-1 immature particle assembly and proper immature lattice formation.

Claim 2morphology observationsupports2025Source 1DOI PubMed

Cryo-ET revealed heterogeneity in HTLV-1 immature particles, including varying lattice curvatures and varying distances from the CA layer to the membrane.

Quoted textsource-backed

Further analysis by cryo-ET reveals clear heterogeneity, notably the varying lattice curvatures and the varying distances from the CA layer to the membrane.

Claim 3structural mechanismsupports2025Source 1DOI PubMed

The HTLV-1 immature CA lattice is stabilized through a trimeric NTD inter-hexamer interface and a dimeric CTD inter-hexamer interface.

Quoted textsource-backed

Our reconstruction reveals that the lattice is stabilized through a trimeric NTD inter-hexamer interface and a dimeric CTD inter-hexamer interface.

Claim 4structural resolutionsupports2025Source 1DOI PubMed

Single particle analysis resolved the HTLV-1 immature CA lattice to 3.4 Å resolution.

Quoted textsource-backed

We report resolving the immature CA lattice to 3.4 Å resolution by single particle analysis (SPA).