We also present a pragmatic framework for the rational application of state-of-the-art tools, including cell-free systems, synthetic microbial consortia, hybrid chemoenzymatic synthesis, and machine learning, to sustainably produce paclitaxel and other natural products.
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hybrid chemoenzymatic synthesis
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The paper presents a pragmatic framework for rational application of cell-free systems, synthetic microbial consortia, hybrid chemoenzymatic synthesis, and machine learning to sustainable paclitaxel and natural product production.
Synthetic biology offers substantial opportunities for de novo paclitaxel production, especially after recent advances in elucidating its biosynthetic pathways.
Paclitaxel supply remains persistently challenging for sustainable production.