First-pass extracted concept

hypothalamic-pituitary-adrenal axis

Candidate: concept label2 source documents2 linked claims

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Aliases

HPA axis

Evidence Snippets

The supplied web research summary identifies the hypothalamic-pituitary-adrenal axis as a related physiological axis connected to the review's discussion of hypothalamic CRH neurons.

Evidence 1Source 1DOI PubMedprovenance

The decline in AEA appears to contribute to activation of the hypothalamic-pituitary-adrenal (HPA) axis, while increased 2-AG signaling contributes to termination and adaptation of the HPA axis.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2019Neurobiology of StressDOI PubMed

1 evidence snippet 0 linked claims

Source 2review2015NeuropsychopharmacologyDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Linked Claims

Claim 1functional rolesupports2015Source 2DOI PubMed

Decline in anandamide appears to contribute to manifestation of the stress response, including HPA-axis activation and increased anxiety behavior.

Claim 2functional rolesupports2015Source 2DOI PubMed

Increased 2-arachidonoyl glycerol signaling contributes to termination and adaptation of the HPA axis and may also contribute to changes in pain perception, memory, and synaptic plasticity.