First-pass extracted concept

ICOS-ICOSL axis

Candidate: concept label1 source documents3 linked claims

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Aliases

ICOS/ICOSL pathway

Evidence Snippets

The tumor cells co-expressed ICOS and ICOSL... These results suggest that the ICOS-ICOSL axis plays an essential role in CTCL pathogenesis, and targeting the ICOS-ICOSL axis could be a viable strategy for treating CTCL.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease severity associationsupports2026Source 1DOI PubMed

Upregulated ICOS and ICOSL expression reflects CTCL disease severity.

Quoted textsource-backed

the upregulated expression of ICOS and ICOSL reflected disease severity

Claim 2expression associationsupports2026Source 1DOI PubMed

CTCL tumor cells co-express ICOS and ICOSL.

Quoted textsource-backed

The tumor cells co-expressed ICOS and ICOSL

Claim 3pathogenesis rolesupports2026Source 1DOI PubMed

The ICOS-ICOSL axis plays an essential role in CTCL pathogenesis and is a potential therapeutic target.

Quoted textsource-backed

These results suggest that the ICOS-ICOSL axis plays an essential role in CTCL pathogenesis, and targeting the ICOS-ICOSL axis could be a viable strategy for treating CTCL.