First-pass extracted concept

ICRAC channel

Candidate: concept label1 source documents4 linked claims

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Aliases

Ca2+-release-activated Ca2+ current, SOC, store-operated Ca2+ channel

Evidence Snippets

TCR-induced Ins(1,4,5)P3 production causes Ca2+ release from intracellular stores, which in turn relays a signal to the plasma membrane store-operated Ca2+ channel (ICRAC channel), causing it to open.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2001ImmunologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1evidence gapmixed2001Source 1DOI PubMed

For B lymphocytes, calcium influx after BCR ligation is observed, but the review states that electrophysiological evidence for ICRAC in B cells was lacking and B-cell expression of this channel was unresolved.

Claim 2mechanistic summarysupports2001Source 1DOI PubMed

In T cells, the TCR-activated calcium influx pathway is strongly supported to be identical to the store-operated ICRAC channel.

Claim 3mechanistic summarysupports2001Source 1DOI PubMed

The initial antigen receptor-driven calcium signal in lymphocytes can involve multiple intracellular calcium channels, while the sustained phase depends on plasma membrane calcium entry together with intracellular channel contributions.

Claim 4signaling modelsupports2001Source 1DOI PubMed

Antigen receptor ligation in lymphocytes induces a biphasic calcium response with an initial intracellular store-release phase followed by a prolonged extracellular calcium-dependent phase.