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First-pass extracted concept

IGEG-2

Candidate: concept label1 source documents4 linked claims
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Aliases

IGEG-2/EGF

Extracted Explainers

What the tool is doing

IGEG-2 is described as a C. elegans EGFR ligand containing Ig and EGF domains. Widespread expression produces phenotypes associated with EGFR hyperactivation.

Source 1DOIPubMed

What it does not solve

The abstract states that the mechanism underlying strict Ig-domain dependence is not known.

Source 1DOIPubMed

Evidence Snippets

<i>C. elegans</i> IGEG-2 is an EGFR ligand of unknown function, identified and named for its Ig and EGF domains.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1activity from expression phenotypesupports2025Source 1DOIPubMed

Widespread expression of IGEG-2 produces phenotypes associated with EGFR hyperactivation, indicating that the EGF domain appears functional.

Quoted textsource-backed
The EGF domain appears to be functional, as widespread expression of IGEG-2 produces phenotypes associated with EGFR hyperactivation.
Claim 2domain requirementsupports2025Source 1DOIPubMed

The immunoglobulin-like domain of IGEG-2 is essential for IGEG-2/EGF signaling.

Quoted textsource-backed
Here we use these phenotypes to investigate the contribution of the IGEG-2 IgD, and we find it to be essential for IGEG-2 /EGF signaling.
Claim 3functional rolesupports2025Source 1DOIPubMed

IGEG-2 is an EGFR ligand in C. elegans.

Quoted textsource-backed
<i>C. elegans</i> IGEG-2 is an EGFR ligand of unknown function, identified and named for its Ig and EGF domains.
Claim 4mechanistic unknownneutral2025Source 1DOIPubMed

The mechanism underlying the strict dependence of IGEG-2 signaling on its immunoglobulin-like domain is unknown.

Quoted textsource-backed
The mechanism underlying this strict IgD dependence is not known.