Immediate-early genes are described as activity-responsive genes whose expression changes rapidly in neurons after activity. In this review they are used mainly as markers of neuronal ensembles linked to learning and memory.
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Immediate early genes
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IEGs
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The expression of Immediate Early Genes (IEGs) such as, c-fos, Egr1 and arc are selectively and promptly upregulated in learning and memory among neuronal subpopulations in regions associated with these processes.
Immediate early genes (IEGs) are critical components of these interactions as they provide the molecular framework for a rapid and dynamic response to neuronal activity while opening the possibility for a lasting and sustained adaptation through regulation of the expression of a wide range of genes.
the expression of immediate-early genes (IEGs) such as egr-1, c-fos, and Arc is rapidly and selectively upregulated in subsets of neurons
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Although many studies support changes in immediate early gene expression during learning and memory, few studies directly analyze the implication of these genes in mental illnesses.
Immediate early genes including c-Fos, Egr1, and Arc are selectively and rapidly upregulated during learning and memory in neuronal subpopulations associated with these processes.
Many psychiatric disorders share deficits in executive functions, emotional control, and memory, and memory deficits may be undervalued relative to other characteristics.
Immediate early genes are tightly associated with neuronal activity, learning, memory, and sensitivity to reward in the central nervous system.
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IEGs have been tightly associated with neuronal activity as well as a variety of higher order processes within the central nervous system such as learning, memory and sensitivity to reward
Immediate early genes provide a rapid and dynamic molecular response to neuronal activity and enable lasting adaptation through regulation of many genes.
Quoted textsource-backed
immediate early genes (IEGs) are critical components of these interactions as they provide the molecular framework for a rapid and dynamic response to neuronal activity while opening the possibility for a lasting and sustained adaptation through regulation of the expression of a wide range of genes
Despite accumulating evidence for the role of immediate-early genes in synaptic plasticity, the molecular and cellular mechanisms associated with this process remain unclear.
Immediate-early gene expression has been widely used as a molecular marker for neuronal populations that undergo plastic changes underlying long-term memory formation.