ICD is described as a form of tumor cell death that enhances antitumor immune responses. In the abstract, SDT-triggered ROS and DAMP release are linked to ICD induction.
First-pass extracted concept
immunogenic cell death
Candidate: concept label5 source documents7 linked claims
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Aliases
ICD
Extracted Explainers
What the tool is doing
What problem it solves
Evidence Snippets
This study aims to develop a nanobubble (NB) delivery system designed to co-administer an immunogenic cell death (ICD) inducer, Shikonin (SK)... The study demonstrated that miR-497/SK-loaded nanobubbles simultaneously boosts ICD and blocks the PD-1/PD-L1 pathway in immunotherapy.
ICD is critical for enhancing antitumor immune responses in tumor immunotherapy.
The concept of immunogenic cell death (ICD) was originally coined by Kroemer in 2005.
The supplied web research summary states that the 2018 NCCD recommendations explicitly cover immunogenic cell death.
Heat shock proteins in the context of photodynamic therapy: autophagy, apoptosis and immunogenic cell death
Supporting Sources
Linked Claims
Sonodynamic therapy uses ultrasound to activate sonosensitizers, generating ROS that induce cytotoxic tumor cell death and trigger immunogenic cell death through DAMP release.
Ultrasound-facilitated activation of shikonin in miR-497/SK-loaded nanobubbles induced injury-related molecular patterns including CRT and HMGB1, consistent with immunogenic cell death.
Immunogenic cell death is characterized by release or enhanced expression of damage-associated molecular patterns including surface-exposed calreticulin, ATP secretion, and HMGB1 release.
Quoted textsource-backed
ICD is characterized by the release and enhanced expression of adjuvant-like damage-associated molecular patterns (DAMPs), which includes but is not limited to surface-exposed calreticulin (ecto-CRT) exposure, ATP secretion, high mobility group protein B1 (HMGB1) release
Released DAMPs in immunogenic cell death promote dendritic cell maturation and tumor antigen presentation, leading to tumor-specific T-cell-mediated antitumor immune responses.
Quoted textsource-backed
these released DAMPs send out "eat me" and "find me" signals that promote dendritic cell (DC) maturation and tumor antigen presentation, ultimately leading to tumor-specific T cell-mediated antitumor immune responses
The scope of ICD inducers has expanded beyond conventional chemotherapeutic drugs to include immunoregulatory biomaterials, biomimetic active materials, supramolecular assembled peptides, photodynamic therapy, photothermal therapy, radiation therapy, and electromagnetic energy.
Quoted textsource-backed
Nowadays, the scope of ICD inducers has expanded beyond conventional chemo drugs such as DOX or Carfilzomib, to include immunoregulatory biomaterials, biomimetic active materials, as well as supramolecular assemble peptides and so forth. Apart from chemotherapy, other therapeutic modalities including photodynamic therapy, photothermal therapy, radiation therapy, as well as electromagnetic energy have shown significant potentials in eliciting robust and remarkable ICD antitumor immune response
This NCCD 2018 recommendations review covers multiple major cell-death modalities including apoptosis, MPT-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, and immunogenic cell death.
Quoted textsource-backed
Anchor article: the 2018 Nomenclature Committee on Cell Death (NCCD) recommendations is a broad consensus review that explicitly covers major regulated cell death modalities including intrinsic/extrinsic apoptosis, MPT-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, and immunogenic cell death.
The review discusses how certain photodynamic therapy protocols may optimally stimulate the immune system through heat shock proteins.
Quoted textsource-backed
We will also discuss how certain PDT protocols optimally stimulate the immune system through HSPs.