First-pass extracted concept

Immunosenescence

Candidate: concept label1 source documents3 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Evidence Snippets

Immunosenescence has been shown to be associated with different pathological conditions and diseases, among which atherosclerosis has recently come to light.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2022Frontiers in ImmunologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic summarysupports2022Source 1DOI PubMed

DNA viruses including CMV, EBV, and HBV are described as upregulating p16, p21, and p53 and inducing inflammaging, metabolic reprogramming, replicative senescence, and telomere shortening.

Claim 2mechanistic summarysupports2022Source 1DOI PubMed

RNA viruses including HCV and HIV are described as inducing ROS generation, DNA damage, SASP, metabolic reprogramming, G1 cell-cycle arrest, telomere shortening, and epigenetic modification.

Claim 3review summarysupports2022Source 1DOI PubMed

The review presents chronic viral infections as shared drivers of immunosenescence and atherogenesis through inflammation, sustained cytokine signaling, ROS generation, and DNA damage.