First-pass extracted concept

immunosenescence in colorectal cancer

Candidate: concept label1 source documents3 linked claims

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Aliases

immunosenescence

Evidence Snippets

Immunosenescence is characterized by the depletion of effector immune cell function and the increase in the proportion of immunosuppressive cells.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1definitionsupports2025Source 1DOI PubMed

Immunosenescence is characterized by depletion of effector immune cell function and increased proportions of immunosuppressive cells.

Claim 2disease mechanismsupports2025Source 1DOI PubMed

Metabolic reprogramming and immunosenescence jointly promote immune escape and therapeutic resistance in colorectal cancer.

Claim 3mechanistic rolesupports2025Source 1DOI PubMed

In colorectal cancer, metabolic reprogramming and immunosenescence are described as key mechanisms in tumorigenesis, development, and treatment resistance.