This approach measures activity patterns in discrete cell types and circuits in living animal models. The abstract frames it as a way to reveal cellular, circuit, and network dysfunction relevant to psychiatric disorders.
First-pass extracted concept
in vivo cell-type-specific calcium imaging
Candidate: concept label1 source documents3 linked claims
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cell-type-specific imaging tools, in vivo calcium imaging studies, large-scale, cell-type specific calcium imaging approaches
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Linked Claims
In vivo calcium imaging studies over the last approximately 10 years indicate that aberrant activity patterns in discrete cell types and circuits may underlie behavioral deficits in animal models of depression, anxiety, autism spectrum disorders, and schizophrenia.
Quoted textsource-backed
Here, we highlight a series of recent findings over the last ~10 years from in vivo calcium imaging studies that show how aberrant patterns of activity in discrete cell types and circuits may underlie behavioral deficits in animal models for several psychiatric disorders, including depression, anxiety, autism spectrum disorders, and schizophrenia.
Cell-type-specific calcium imaging tools in pre-clinical models provide blueprints for developing more targeted therapeutics and treatment strategies.
Quoted textsource-backed
These advances in calcium imaging in pre-clinical models demonstrate the power of cell-type-specific imaging tools in understanding the underlying dysfunction in cell types, activity patterns, and neural circuits that may contribute to disease and provide new blueprints for developing more targeted therapeutics and treatment strategies.
Recent large-scale cell-type-specific calcium imaging approaches have revealed cellular, circuit, and network-level dysfunction in animal models for psychiatric disorders.
Quoted textsource-backed
Recent advances in large-scale, cell-type specific calcium imaging approaches have shed new light on the cellular, circuit, and network-level dysfunction in animal models for psychiatric disorders.