The source presents indole as a medicinal-chemistry scaffold used in many FDA-approved drugs. It is framed as a versatile structural motif rather than a standalone tool.
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indole
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Numerous indole-containing drugs have been approved by the FDA across oncology, infectious diseases, gastrointestinal disorders, neurological conditions, and cardiovascular diseases.
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Over the past decades, numerous indole-containing drugs have been approved by the Food and Drug Administration (FDA), spanning diverse therapeutic areas including oncology, infectious diseases, gastrointestinal disorders, neurological conditions, and cardiovascular diseases.
The review surveys FDA-approved indole-based drugs with particular emphasis on approvals from 2013 to the present and discusses synthetic strategies, pharmacology, mechanisms of action, and clinical applications.
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This review provides a comprehensive survey of FDA-approved indole-based drugs, with particular emphasis on those approved from 2013 to the present. Representative synthetic strategies are highlighted to illustrate the versatility of the indole framework in drug design. Furthermore, we systematically discuss each drug's pharmacology, mechanisms of action, and clinical applications.
Indole is described as a privileged heteroaromatic scaffold in medicinal chemistry with unique physicochemical properties, hydrogen-bonding potential, and bioisosteric versatility.
Quoted textsource-backed
Indole is a privileged heteroaromatic scaffold in medicinal chemistry, characterised by its unique physicochemical properties, hydrogen-bonding potential, and bioisosteric versatility.