First-pass extracted concept

induced pluripotent stem cell-derived peripheral sensory neurons

Candidate: concept label1 source documents3 linked claims

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Aliases

iPSC-PSNs

Extracted Explainers

What the tool is doing

iPSC-PSNs are used here as the neuronal test system for exposing sensory neurons to CXCL9, CXCL10, and macrophage-conditioned media.

Source 1DOI PubMed

Resources required

The model requires induced pluripotent stem cell-derived peripheral sensory neuron cultures and expression assays for TRPV1/TRPA1.

Source 1DOI PubMed

What problem it solves

It allows direct neuron-focused testing of candidate inflammatory mediators identified from the in vivo DRG analysis.

Source 1DOI PubMed

Evidence Snippets

we treated induced pluripotent stem cell-derived peripheral sensory neurons (iPSC-PSNs) with CXCL9 and CXCL10

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1conditioned media effectsupports2026Source 1DOI PubMed

Conditioned media from IFNγ-treated monocyte-derived macrophages modestly increased TRPV1 expression in iPSC-derived peripheral sensory neurons.

Quoted textsource-backed

Conditioned media from IFNγ-treated MDMs modestly increased TRPV1 expression in iPSC-PSNs

Claim 2expression changesupports2026Source 1DOI PubMed

CXCL9 and CXCL10 treatment increased TRPV1 expression but not TRPA1 expression in iPSC-derived peripheral sensory neurons.

Quoted textsource-backed

we treated induced pluripotent stem cell-derived peripheral sensory neurons (iPSC-PSNs) with CXCL9 and CXCL10, which induced a significant increase in TRPV1 but not TRPA1 expression

Claim 3pharmacological perturbationsupports2026Source 1DOI PubMed

Pharmacological inhibition of CXCR3 did not reduce the conditioned-media-induced increase in TRPV1 expression in iPSC-derived peripheral sensory neurons.

Quoted textsource-backed

pharmacological inhibition of CXCR3, the receptor of CXCL9/10, did not reduce this effect