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First-pass extracted concept

infralimbic cortex

Candidate: concept label2 source documents6 linked claims
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Aliases

IL

Extracted Explainers

What the tool is doing

The infralimbic cortex is presented as an mPFC subregion with reduced activity in chronic pain.

Source 1DOIPubMed

The review describes infralimbic cortex as a medial prefrontal subdivision biased toward suppression of fear. It is discussed as part of the PL/IL dichotomy in fear conditioning and extinction.

Source 2DOIPubMed

What problem it solves

It supports the review's subregional description of mPFC dysfunction associated with chronic pain.

Source 1DOIPubMed

This concept helps organize evidence about which mPFC subregion is associated with suppression of conditioned fear and extinction-related control.

Source 2DOIPubMed

What it does not solve

The abstract does not describe a specific manipulation, assay, or therapeutic platform for IL.

Source 1DOIPubMed

The abstract does not present IL as a discrete tool, delivery system, or assay.

Source 2DOIPubMed

Alternatives

The main contrasted subdivision in the abstract is prelimbic cortex, which is described as biased toward fear expression.

Source 2DOIPubMed

Evidence Snippets

The medial prefrontal cortex... comprises the anterior cingulate cortex, the prelimbic, and the infralimbic cortex... prelimbic, and infralimbic regions show reduced activity.
Evidence 1Source 1DOIPubMedprovenance
A division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
Evidence 2Source 2DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1activity state summarysupports2020Source 1DOIPubMed

In chronic pain, anterior cingulate cortex appears hyperactive whereas prelimbic and infralimbic regions show reduced activity.

Quoted textsource-backed
While the anterior cingulate cortex appears hyperactive, prelimbic, and infralimbic regions show reduced activity.
Claim 2anatomical change summarysupports2020Source 1DOIPubMed

Chronic pain conditions are associated with gray matter loss in anterior cingulate, prelimbic, and infralimbic regions of the medial prefrontal cortex.

Quoted textsource-backed
magnetic resonance imaging has revealed gray matter loss in all these areas in chronic pain conditions
Claim 3functional bias summarysupports2015Source 2DOIPubMed

A proposed division of labor assigns prelimbic cortex to fear expression and infralimbic cortex to fear suppression in rodents.

Quoted textsource-backed
Importantly, a division of labor has been proposed in which the prelimbic (PL) and infralimbic (IL) subdivisions of the medial prefrontal cortex (mPFC) regulate the expression and suppression of fear in rodents, respectively.
Claim 4functional covariation summarysupports2015Source 2DOIPubMed

Under some conditions, prelimbic and infralimbic cortex act in concert and show similar neural activity patterns in response to aversive conditioned stimuli and during expression or inhibition of conditioned fear.

Quoted textsource-backed
We propose that under some conditions, the PL and IL act in concert, exhibiting similar patterns of neural activity in response to aversive conditioned stimuli and during the expression or inhibition of conditioned fear.
Claim 5mechanistic hypothesis summarysupports2015Source 2DOIPubMed

Shared synaptic inputs, parallel downstream outputs, or cortico-cortical interactions may explain similar activity patterns between prelimbic and infralimbic cortex.

Quoted textsource-backed
This may stem from common synaptic inputs, parallel downstream outputs, or cortico-cortical interactions.
Claim 6qualified opposition summarysupports2015Source 2DOIPubMed

Despite functional covariation, prelimbic and infralimbic cortex may still code for largely opposing behavioral outcomes, with prelimbic biased toward fear expression and infralimbic toward suppression.

Quoted textsource-backed
Despite this functional covariation, these mPFC subdivisions may still be coding for largely opposing behavioral outcomes, with PL biased towards fear expression and IL towards suppression.