Inherited retinal degenerations (IRDs) encompass a large group of clinically and genetically heterogeneous diseases... Although IRDs remain untreatable today, significant progress toward therapeutic strategies for IRDs has marked the past two decades.
First-pass extracted concept
Inherited retinal degenerations
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IRDs
Evidence Snippets
Supporting Sources
Linked Claims
Inherited retinal degenerations affect approximately 1 in 3000 people worldwide, totaling more than 2 million people.
Quoted textsource-backed
Inherited retinal degenerations (IRDs) encompass a large group of clinically and genetically heterogeneous diseases that affect approximately 1 in 3000 people (>2 million people worldwide)
Inherited retinal degenerations may affect the entire retina or be restricted to the macula and ultimately lead to blindness.
Quoted textsource-backed
IRDs may affect the entire retina... or be restricted to the macula... ultimately leading to blindness.
Inherited retinal degenerations are clinically and genetically heterogeneous and can be inherited as Mendelian traits or through mitochondrial DNA.
Quoted textsource-backed
IRDs encompass a large group of clinically and genetically heterogeneous diseases... IRDs may be inherited as Mendelian traits or through mitochondrial DNA
Progress toward therapeutic strategies for inherited retinal degenerations has been driven by improved understanding of disease pathophysiology and technological advances.
Quoted textsource-backed
This progress has been based on better understanding of the pathophysiological pathways of these diseases and on technological advances.
As of the review, inherited retinal degenerations remained untreatable, but substantial progress toward therapeutic strategies had occurred over the prior two decades.
Quoted textsource-backed
Although IRDs remain untreatable today, significant progress toward therapeutic strategies for IRDs has marked the past two decades.