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Inhibitor of Apoptosis (IAP) family proteins

Candidate: concept label1 source documents5 linked claims
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Aliases

IAP family proteins, IAPs

Extracted Explainers

What the tool is doing

The review describes IAP family proteins as suppressors of apoptosis. It frames them as regulators of the physiological cell suicide program.

Source 1DOIPubMed

What problem it solves

In the source abstract, IAPs are presented as proteins that inhibit cell death pathways and suppress host cell death responses to viral infection.

Source 1DOIPubMed

What it does not solve

The abstract does not establish a settled molecular mechanism for how IAPs suppress cell death, noting that the mechanism remains debated.

Source 1DOIPubMed

Alternatives

The abstract does not name alternative apoptosis-suppressing tool classes; it only situates IAPs among proteins involved in apoptosis regulation.

Source 1DOIPubMed

Evidence Snippets

This review discusses the Inhibitor of Apoptosis (IAP) family of proteins.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1cross species activitysupports1999Source 1DOIPubMed

Some baculoviral IAPs can block apoptosis when ectopically expressed in mammalian cells, supporting conservation of the cell death program across species.

Quoted textsource-backed
Interestingly, ectopic expression of some baculoviral IAPs blocks apoptosis in mammalian cells, suggesting conservation of the cell death program among diverse species and commonalities in the mechanism used by the IAPs to inhibit apoptosis.
Claim 2disease relevancesupports1999Source 1DOIPubMed

Reports summarized in the review suggest that IAPs have important roles in some human diseases.

Quoted textsource-backed
Moreover, a variety of reports have suggested an important role for the IAPs in some human diseases.
Claim 3mechanism statusmixed1999Source 1DOIPubMed

The mechanism by which IAPs suppress cell death remained debated at the time of the review, although biochemical insights had been reported.

Quoted textsource-backed
Although the mechanism used by the IAPs to suppress cell death remains debated, several studies have provided insights into the biochemical functions of these intriguing proteins.
Claim 4origin and functionsupports1999Source 1DOIPubMed

IAPs were first discovered in baculoviruses and were shown to suppress the host cell death response to viral infection.

Quoted textsource-backed
First discovered in baculoviruses, IAPs were shown to be involved in suppressing the host cell death response to viral infection.
Claim 5review summarysupports1999Source 1DOIPubMed

IAP family proteins are discussed as suppressors of apoptosis and as biologically important regulators of cell death with therapeutic relevance.

Quoted textsource-backed
Thus, proteins involved in apoptosis regulation are of intense biological interest and many are attractive therapeutic targets. This review discusses the Inhibitor of Apoptosis (IAP) family of proteins.