First-pass extracted concept

inhibitory optogenetics

Candidate: concept label2 source documents4 linked claims

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Evidence Snippets

Since the ion transport by these pumps induces hyperpolarization of membrane potential and inhibit neural firing, light-driven ion-pumping rhodopsins are mostly applied as inhibitory optogenetics tools.

Evidence 1Source 1DOI PubMedprovenance

The source title and supplied summary together indicate a review of genetically encoded molecular tools for optical silencing of neurons.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2021Advances in experimental medicine and biologyDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2review2012Progress in brain researchDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Linked Claims

Claim 1application scopesupports2021Source 1DOI PubMed

Light-driven ion-pumping rhodopsins are mostly applied as inhibitory optogenetics tools.

Claim 2functional effectsupports2021Source 1DOI PubMed

Ion transport by light-driven ion-pump rhodopsins induces membrane hyperpolarization and inhibits neural firing.

Claim 3property axes reviewedsupports2012Source 2DOI PubMed

The review discusses expression, trafficking, spectra, kinetics, and engineering as relevant properties of inhibitory optogenetic silencing tools.

Claim 4review scopesupports2012Source 2DOI PubMed

This review centers on inhibitory microbial opsins used for light-driven silencing of targeted neurons.