Here, we review knowledge emerging from investigations of the role of the kinin system in the mechanisms that link innate to the adaptive phase of immunity.
First-pass extracted concept
innate kinin pathway
Candidate: concept label1 source documents4 linked claims
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Evidence Snippets
Supporting Sources
Linked Claims
Bradykinin acts as an endogenous danger signal that induces dendritic cell maturation through bradykinin B2 receptors.
Quoted textsource-backed
bradykinin is an endogenous danger signal that induces dendritic cell (DC) maturation via G protein-coupled bradykinin B2 receptors (B2R)
Failure of dendritic cells from B2R-deficient mice to sense parasite-released kinin danger signals is associated with lower frequencies of interferon-gamma-producing effector T cells.
Quoted textsource-backed
DCs from B2R-/- mice (susceptible phenotype) failed to sense kinin 'danger' signals proteolytically released by parasites, explaining why these mutant mice display lower frequencies of interferon-gamma-producing effector T-cells
In mouse models of Trypanosoma cruzi infection, kinins have an immunostimulatory role.
Quoted textsource-backed
The immunostimulatory role of kinins was recently confirmed in two different mouse models of Trypanosoma cruzi infection
The balance between cruzipain-mediated kinin generation and angiotensin-converting enzyme-mediated kinin degradation governs dendritic cell maturation and TH1 development through a B2R-dependent innate pathway.
Quoted textsource-backed
the balance between cruzipain and angiotensin-converting enzyme, respectively acting as kinin-generating and degrading enzymes, governs extent of DC maturation and TH1 development via the B2R-dependent innate pathway