First-pass extracted concept

inorganic fluoride

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Nephrotoxicity may occur because of metabolic liberation of inorganic fluoride, as has been shown for methoxyflurane.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review1995Anesthesia & AnalgesiaDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1clinical status summarysupports1995Source 1DOI PubMed

Methoxyflurane clinical use was discontinued because of rare severe hepatotoxicity and dose-dependent nephrotoxicity.

Claim 2evidence gap summaryneutral1995Source 1DOI PubMed

The review discusses the potential toxicity of sevoflurane in light of known mechanisms from other inhaled anesthetics rather than concluding established human organ toxicity.

Claim 3mechanism summarysupports1995Source 1DOI PubMed

Methoxyflurane nephrotoxicity is linked to metabolic liberation of inorganic fluoride.