A plethora of studies of AgR signalling have highlighted the role of inositol trisphosphate [Ins(1,4,5)P3]-mediated release of Ca2+ from internal stores.
First-pass extracted concept
inositol trisphosphate receptor
Candidate: concept label1 source documents4 linked claims
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Aliases
Ins(1,4,5)P3 receptor, InsP3R
Evidence Snippets
Supporting Sources
Linked Claims
InsP3 receptor isoforms are presented as regulators of temporal and spatial calcium signaling, with differing calcium sensitivities that may help tune oscillatory versus transient responses.
The initial antigen receptor-driven calcium signal in lymphocytes can involve multiple intracellular calcium channels, while the sustained phase depends on plasma membrane calcium entry together with intracellular channel contributions.
Antigen receptor ligation in lymphocytes induces a biphasic calcium response with an initial intracellular store-release phase followed by a prolonged extracellular calcium-dependent phase.
The review treats plasma membrane InsP3 receptors, l-type calcium channels, CD20, and annexin V as possible or proposed lymphocyte calcium channels, but emphasizes that their roles or bona fide channel identities remain uncertain or speculative.