First-pass extracted concept

insomnia as a transdiagnostic phenotype

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Present day research takes the view on insomnia... as a transdiagnostic symptom for many mental disorders, being most closely related to depression. Studying insomnia from different angles as a transdiagnostic phenotype has opened many new perspectives for research into mechanisms but also for clinical practice.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2019NeuropsychopharmacologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease relationshipsupports2019Source 1DOI PubMed

The review presents insomnia as a transdiagnostic symptom across many mental disorders and as being most closely related to depression.

Claim 2prevention questionneutral2019Source 1DOI PubMed

The review explicitly raises the question of whether early and adequate treatment of insomnia can prevent depression.

Claim 3treatment associationsupports2019Source 1DOI PubMed

Almost all antidepressant agents suppress REM sleep, and the review states that a time-and-dose-response relationship between total REM sleep suppression and therapeutic response seemed apparent.