HSL is tightly controlled by insulin regulation via the central and peripheral systems.
First-pass extracted concept
Insulin
Candidate: concept label1 source documents4 linked claims
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Evidence Snippets
Supporting Sources
Linked Claims
Insulin's inhibitory effect on HSL can be overridden in the context of insulin-induced hypoglycemia.
Quoted textsource-backed
a rapid elevation of HSL levels was detected after insulin injection in patients, which suggests that the inhibitory effects of insulin on HSL can be overridden by insulin-induced hypoglycemia
Recent discoveries challenge the assumptions that HSL is the overall rate-limiting enzyme in lipolysis and that insulin is simply an inhibitor of HSL.
Quoted textsource-backed
The common beliefs that HSL is the overall rate-limiting enzyme in lipolysis and that insulin is an inhibitor of HSL have been challenged by recent discoveries
Insulin regulates HSL at multiple levels including isoform transcription, post-transcriptional phosphorylation effects involving PKA and endothelin, and indirect control through growth hormone activity.
Quoted textsource-backed
Insulin not only differentially regulates HSL isoform transcription but also post-transcriptionally affects HSL phosphorylation by stimulating PKA and endothelin (ET-1), and controls its expression indirectly via regulating the activity of growth hormone (GH).
Insulin tightly regulates hormone-sensitive lipase through central and peripheral mechanisms.
Quoted textsource-backed
HSL is tightly controlled by insulin regulation via the central and peripheral systems.