we propose an integrated optimization framework built on three synergistic pillars
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integrated optimization framework
Candidate: concept label1 source documents4 linked claims
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PSMA-targeted CAR-T therapy has transformative potential for metastatic castration-resistant prostate cancer but remains at a pivotal translational stage requiring integrated optimization.
Quoted textsource-backed
PSMA-targeted CAR-T therapy holds transformative potential for mCRPC but remains at a pivotal translational juncture. To realize this potential, an integrated strategy is imperative
The review proposes an integrated optimization framework for PSMA-targeted CAR-T therapy built on precision CAR engineering, tumor microenvironment remodeling, and manufacturing and delivery innovation.
Quoted textsource-backed
we propose an integrated optimization framework built on three synergistic pillars: (1) precision CAR engineering (e.g., logic-gated constructs, safety switches); (2) remodeling the tumor microenvironment (e.g., armored CAR-T cells, rational combinations); and (3) innovating manufacturing and delivery (e.g., allogeneic products, enhanced persistence)
High and specific overexpression of PSMA on tumor cells provides a rationale for targeted immunotherapy in metastatic castration-resistant prostate cancer.
Quoted textsource-backed
The high, specific overexpression of prostate-specific membrane antigen (PSMA) on tumor cells provides a compelling rationale for targeted immunotherapy.
Translation of PSMA-directed CAR-T cell therapy to the clinic faces substantial solid-tumor barriers including a suppressive tumor microenvironment, antigen heterogeneity, and T-cell exhaustion.
Quoted textsource-backed
the translation of PSMA-directed chimeric antigen receptor T (CAR-T) cell therapy from bench to bedside faces substantial barriers typical of solid tumors... key translational gaps—including a suppressive tumor microenvironment, antigen heterogeneity, and T-cell exhaustion