First-pass extracted concept

interchromatin compartment

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Evidence Snippets

Three-dimensional structured illumination microscopy (3D-SIM) demonstrated a network of channels and wider lacunas, called the interchromatin compartment (IC).

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2010Cold Spring Harbor Symposia on Quantitative BiologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1molecular enrichmentsupports2010Source 1DOI PubMed

Nascent DNA, nascent RNA, RNA polymerase II, and histone modifications associated with transcriptionally competent or active chromatin are highly enriched in the perichromatin region, while splicing speckles are observed in the interior of the interchromatin compartment.

Quoted textsource-backed

Nascent DNA, nascent RNA, RNA polymerase II (RNA Pol II), as well as histone modifications for transcriptionally competent/active chromatin, are highly enriched in the PR, whereas splicing speckles are observed in the interior of the IC.

Claim 2structural localizationsupports2010Source 1DOI PubMed

3D-SIM revealed an interchromatin compartment network of channels and wider lacunas that starts at nuclear pores and expands throughout the nuclear space.

Quoted textsource-backed

Three-dimensional structured illumination microscopy (3D-SIM) demonstrated a network of channels and wider lacunas, called the interchromatin compartment (IC). The IC starts at nuclear pores and expands throughout the nuclear space.

Claim 3structural measurementsupports2010Source 1DOI PubMed

The perichromatin region is a 100-200 nm thick layer of decondensed chromatin that demarcates the interchromatin compartment from the compact interior of chromatin domains.

Quoted textsource-backed

It is demarcated from the compact interior of higher-order chromatin domains (CDs) by a 100-200-nm thick layer of decondensed chromatin, termed the perichromatin region (PR).