First-pass extracted concept

intersectional targeting of defined neural circuits

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Aliases

intersectional approaches

Evidence Snippets

These intersectional approaches specifically target AAV-mediated gene expression to discrete neuron populations based on their axonal connectivity

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2020Journal of Neuroscience ResearchDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1capabilitysupports2020Source 1DOI PubMed

These approaches allow direct control over the number of labeled neurons for tracing axonal projections and examining cellular morphology.

Quoted textsource-backed

The number of labeled neurons can be directly controlled to trace axonal projections and examine cellular morphology.

Claim 2payload scopesupports2020Source 1DOI PubMed

Intersectional AAV circuit-targeting approaches can target expression of fluorescent reporters, optogenetic ion channels, chemogenetic receptors, disease-associated proteins, and other factors to defined neural circuits.

Quoted textsource-backed

These approaches can precisely target the expression of fluorescent reporters, optogenetic ion channels, chemogenetic receptors, disease-associated proteins, and other factors to defined neural circuits

Claim 3review scope summarysupports2020Source 1DOI PubMed

The review covers axonal-transport-based intersectional AAV approaches for targeting neuron populations defined by connectivity.

Quoted textsource-backed

We review emerging techniques that use the axonal transport of adeno-associated virus (AAV) vectors to dissect neural circuits. These intersectional approaches specifically target AAV-mediated gene expression to discrete neuron populations based on their axonal connectivity

Claim 4species scopesupports2020Source 1DOI PubMed

The reviewed approaches are described as applicable in mammals ranging from mice to macaques.

Quoted textsource-backed

in mammals ranging from mice to macaques

Claim 5targeting modessupports2020Source 1DOI PubMed

The reviewed intersectional approaches include targeting neurons with one defined output, one defined input, one defined input and one defined output, and two defined inputs or outputs.

Quoted textsource-backed

including: (a) neurons with one defined output, (b) neurons with one defined input, (c) neurons with one defined input and one defined output, and (d) neurons with two defined inputs or outputs