First-pass extracted concept

Intestinal stem cells

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

However, attempts to model signals definitively that control intestinal stem cells have been difficult because of a long-standing and recently reenergized debate surrounding their location.

Evidence 1Source 1DOIprovenance

Supporting Sources

Source 1review2008GastroenterologyDOI

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1cell identity modelsupports2008Source 1DOI

Long-term label-retaining cells at the +4 position are supported by a large body of evidence as putative intestinal stem cells.

Claim 2knowledge gapsupports2008Source 1DOI

Definitive modeling of the signals controlling intestinal stem cells has been difficult because their anatomical location remains debated.

Claim 3review scope summarysupports2008Source 1DOI

Mouse studies have provided substantial information about Wnt, bone morphogenic protein, PtdIns(3,4,5) kinase, and Notch signaling in intestinal development and homeostasis, including stem cell regulation and lineage specification and maturation.

Claim 4synthesis modelsupports2008Source 1DOI

The review proposes that crypt-based columnar cells and +4 label-retaining cells both represent true intestinal stem cells maintained in different states, quiescent versus actively cycling, likely through different microenvironments.