First-pass extracted concept

intracellular Amyloid-b2 oligomers

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

We applied this system to the crucial question of how intracellular Amyloid-b2 oligomers underlie the pathologies of A.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2020MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease modelingsupports2020Source 1DOI PubMed

Physical damage caused by Amyloid-b2 oligomers recapitulated catastrophic tissue loss described as a hallmark of late Alzheimer's disease.

Claim 2mechanistic separationsupports2020Source 1DOI PubMed

The optogenetic Amyloid-b2 system enabled separation of metabolic and physical damage caused by light-induced Amyloid-b2 oligomerization from damage caused by Amyloid-b2 expression alone.

Claim 3perturbation responsesupports2020Source 1DOI PubMed

Li+ treatment reduced the lifespan deficit induced by Amyloid-b2 oligomers.